一、教育、工作經曆：

2024年1月 – 至今            太阳成集团tyc234cc 生命健康技術學院 學科領軍，教授，博士後合作導師

2015年7月 – 2024年1月  中北大學 信息與通信工程學院 教授，博士生導師

2013年7月－2015年6月  美國肯塔基大學 生物醫學工程系，研究員(Scientist I)

2011年7月－2013年6月  美國心髒協會/肯塔基大學，博士後研究員(Postdoctoral Fellow)

2008年7月－2011年6年  美國肯塔基大學，生物醫學工程中心，博士後學者(Postdoctoral Scholar)

2004年9月－2008年7月  清華大學，生物醫學工程專業，工學博士

2001年9月－2004年7月  吉林大學 生物醫學工程專業，工學碩士

2000年6月－2004年8月  吉林大學，數學科學學院，教師

1999年7月－2000年6月  長春科技大學，應用理學院，教師

1995年9月－1999年7月  吉林大學，應用數學專業，理學學士

二、研究領域：

開發近紅外漫射光譜(near-infrared diffuse optical spectroscopy-NIRS)以及相關光譜與成像(diffuse correlation spectroscopy/ tomography, DCS/DCT)技術探測生物組織的血流動力學信息(包括血流、血氧和氧代謝)。NIRS是根據光子在生物組織内輸運過程中吸收和散射的特性來測量血氧含量的傳統方法；DCS/DCT是根據光場時間自相關函數在動态散射體擴散原理測量血流的新技術。本團隊長期從事NIRS和 DCS/DCT技術的開發，并将這些技術成功地應用于臨床。具體包括：

1. 光學儀器設計；包括優化激光器、光子探測器和數字相關器的配置及軟件控制，實現快速和高效的光子數據獲取。

2. 光場的物理建模及信息計算；通過分析生物組織内運動的紅細胞對光場相關性的影響，建立動态光散射的數學模型和血流信息計算方法。

3. 醫學計算成像及信号和圖像處理；系統地考察光學信号的噪聲來源以及對血流測量的影響，并在此基礎上開發與生理狀态相關聯的DCS血流測量方式和去噪算法；以及開發結合形态學影像的精确DCT血流計算成像方法和圖像處理方法。

4. 漫射光技術的臨床應用；将開發的NIRS和DCS/DCT技術應用于腦、骨骼肌及腫瘤等組織和器官，進行多種的疾病早期診斷和治療評估。

三、主要業績：

近年來的主要工作是：發展近紅外漫射光技術來無創檢測生物組織的血流、血氧和代謝，并應用于臨床，進行多種疾病早期診斷和治療評估。 曾經主持美國心髒協會（AHA）的基金一項，參與美國國立衛生院（NIH）等機構的基金三項；作為負責人和首席科學家，2016年和2023年先後承擔國家重點研發計劃“數字診療裝備研發”和“戰略性科技創新合作”兩個重點專項，以及國家自然科學基金、山西省重點研發計劃、山西省基礎研究計劃、企業橫向等科研項目；發表SCI論文50餘篇，SCI引用1300餘次。曾任IEEE等3個國際會議的委員會主席或執行委員。中國醫療保健國際交流促進會重症醫學專業委員會常委、微電子與光電子材料與器件專家委員會副主任委員、中國光學學會光電技術專業委員會委員，中國儀器儀表學會光機電技術與系統集成分會理事，中國光學學會生物醫學光子學專業委員會委員，中國體視學學會智能成像專業委員會委員；目前擔任5種國際期刊的編委/客座編輯和20餘種國際期刊的審稿人。2017年聘任“山西特聘專家”，2018年入選“三晉英才”人才計劃和中共山西省委聯系的高級專家。

四、講授課程：

1. 本科生：《生物醫學工程專業英語》、《生物醫學工程創新教育實踐》、《複變函數》、《數學物理方程》、《概率統計》、《數字信号處理》

2. 研究生：《科技外語寫作》、《計算成像理論和方法》（留學生，全英文）、《數值分析》（留學生，全英文）

五、代表性研究成果：

（一）SCI期刊論文 （* 通訊作者）

1. W Li , Z Zhang , Z Li , Z Gui , Y Shang^* . Correlation and asynchronization of electroencephalogram and cerebral blood flow in active and passive stimulations. Journal of Neural Engineering 20(6), 066007,2023.

2. X Zhao , G Hao, Y Shang^* , J Han^*. Three-Dimensional Gradient Metamaterial Devices Coupled with Phononic Crystals for Acoustic Enhancement Sensing. Crystals. 13(8):1191,2023.

3. S. Feng, Z. Gui,  X. Zhang , Y. Shang^*, "Collimating micro-lens fiber array for noncontact near-infrared diffuse correlation tomography", Biomedical Optics Express, 12(3), 1467-1481,2021.

4. J. Bai,  Q. Zhu, Y. Liu, Y. Zhou,T. Shi, Z. Gui, Y. Shang^*, " PV-MBLL algorithm for extraction of absolute tissue oxygenation information by diffuse optical spectroscopy". Computer methods and programs in biomedicine, 193, 105456, 2020.

5. X. Zhang, L. Zhai,  J. Wang, G. Lou, Y. Shang, Z. Gui, ART-TV algorithm for diffuse correlation tomography blood flow imaging. IEEE Access, 8, 136819-136827,2020.

6. A. A. Bahrani, W. Kong, Y. Shang,C. Huang ,C. D.  Smith, D. K. Powell, &  G.  Yu, Diffuse optical assessment of cerebral‐autoregulation in older adults stratified by cerebrovascular risk. Journal of Biophotonics, 13(10), e202000073,2020.

7. J. Zuo, X. Zhang, J. Lu, Z. Gui, Y. Shang^*,"Impact of Reconstruction Algorithms on Diffuse Correlation Tomography Blood Flow Imaging", IEEE Access, 8, 31882- 31891, 2020.

8. H. Ling, Z. Gui, H. Hao, Y. Shang^*," Enhancement of diffuse correlation spectroscopy tissue blood flow measurement by acoustic radiation force ", Biomedical Optics Express 11 (1), 301-315,2020.

9. Y. Zhu, Z. Gui, B. Xue, Y. Shang^*,"Experimental Validation of Microvasculature Blood Flow Modeling by Diffuse Correlation Spectroscopy", IEEE Access,8, 15945-15951, 2020.

10. L. Hou, Y. Liu, L. Qian, Y. Zheng, J. Gao, W. Cao, Y. Shang^*, "Portable near-infrared technologies and devices for noninvasive assessment of tissue hemodynamics"，Journal of Healthcare Engineering , 2019,3750495,2019.

11. P. Zhang, Z. Gui, G. Guo, Y. Shang^*. Approaches to denoise the diffuse optical signals for tissue blood flow measurement, Biomedical Optics Express, 9(12), 6170-6185,2018.

12. Y. Shang^*, "Advances in Reconstructed Algorithms for Diffuse Correlation Spectroscopy and Tomography", Lecture Notes in Electrical Engineering, 506,15-28,2018.

13. J. Li, W. Han, Y. Li,Y. Chen, Y. Shang, Y Chen, Z. Gui, "Inverse problem based on the fast alternating direction method of multipliers algorithm in multiangle total internal reflection fluorescence microscopy," Applied Optics, 57(33), 9828-34, 2018.

14. L. Jia, Q. Zhang, Y. Shang, Y. Wang, Y. Liu ; N. Wang, Z. Gui, G.Yang, "Denoising for Low-Dose CT Image by Discriminative Weighted Nuclear Norm Minimization," IEEE Access,6, 46179-93,2018.

15. N. Wang, Y. Shang, Y. Chen, M. Yang, Q. Zhang, Y. Liu, Z. Gui, “A Hybrid Model for Image Denoising Combining Modified Isotropic Diffusion Model and Modified Perona-Malik Model”, IEEE Access,6, 33568-82,2018.

16. T. Li, P. Wang,L. Qiu, X. Fang,and Y. Shang, “Optimize Illumination Parameter of Low-Level Laser Therapy for Hemorrhagic Stroke by Monte Carlo Simulation on Visible Human Dataset”, IEEE Photonics Journal,10(3), 6100409 ,2018.

17. X. Zhang, Z. Gui, Z. Qiao, Y.Liu, and Y. Shang*, Nth-order linear algorithm for diffuse correlation tomography, Biomedical Optics Express, 9(5), 2365-2382,2018.

18. J. Guo, Z. Gui, H. Hou, Y. Shang^*, “Flexible positioning of source-detector arrays in 3D visualization platform for Monte Carlo simulation of light propagation,” IEEE Access,5,26673-80,2017.

19. S. Luo, X. Shen, X. Bai, J. Bai, J. Han,and Y. Shang^*, “Validation of material algorithms for femur remodelling Using Medical Image Data”, Applied Bionics and Biomechanics,2017, 5932545, 2017.

20. Y. Shang, T. Li, G. Yu, "Clinical applications of near-infrared diffuse correlation spectroscopy and tomography for tissue blood flow monitoring and imaging," Physiological Measurement, 1361-6579, 2017.

21. C. Huang, D. Irwin, M. Zhao, Y. Shang, N. Agochukwu, L. Wong, G. Yu, "Noncontact 3-dimensional Speckle Contrast Diffuse Correlation Tomography of Tissue Blood Flow Distribution", IEEE Transactions on Medical Imaging,2017.

22. L. Dong, M. Kudrimoti, D. Irwin, L. Chen, S. Kumar, Y. Shang, C. Huang, E. Johnson, S. Stevens, B. Shelton, G. Yu, “Diffuse optical measurements of head and neck tumor hemodynamics for early prediction of chemo-radiation therapy outcomes,” Journal of Biomedical Optics, 21(8), 085004,2016.

23. B. Henry, M. Zhao, Y. Shang, et al. “Hybrid diffuse optical techniques for continuous hemodynamic measurement in gastrocnemius during plantar flexion exercise” Journal of Biomedical Optics 20(12), 125006,2015.

24. C. Huang, D. Irwin, Y. Lin, Y. Shang, L. He, W. Kong, J. Luo, G. Yu, “Speckle contrast diffuse correlation tomography of complex turbid medium flow,” Medical Physics, 42(7), 4000,2015.

25. C. Huang, J. P. Radabaugh, R. K. Aouad, Y. Lin, T. J. Gal, A. B. Patel, J. Valentino, Y. Shang, G. Yu, “Noncontact Diffuse Optical Assessment of Blood Flow Changes in Head and Neck Free Tissue Transfer Flaps,” Journal of Biomedical Optics, 20(7), 075008,2015.

26. Y. Shang and G. Yu, “A Nth-order linear algorithm for extracting diffuse correlation spectroscopy blood flow indices in heterogeneous tissues,” Applied Physics Letters, 105, 133702,2014.

27. Y. Shang, T. Li, L. Chen, Y. Lin, M. Toborek, G. Yu, “Extraction of diffuse correlation spectroscopy flow index by integration of Nth-order linear model with Monte Carlo simulation,” Applied Physics Letters, 104, 193703,2014.

28. Y. Hou*, Y. Shang*, R. Cheng, Y. Zhao, Y. Qin, R. Kryscio, A. Rayapati, D. Hayes Jr, G. Yu, “Obstructive sleep apnea–hypopnea results in significant variations in cerebral hemodynamics detected by diffuse optical spectroscopies,” Physiological Measurement, 35, 2135,2014. *Contributed equally

29. R. Cheng, Y. Shang, S. Wang, J. M. Evans, A. Rayapati, D.C. Randall, G. Yu, “Near-infrared diffuse optical monitoring of cerebral blood flow and oxygenation for the prediction of vasovagal syncope”, Journal of Biomedical Optics 19(1), 017001,2014.

30. Y. Lin, C. Huang, D. Irwin, L. He, Y. Shang, G. Yu, “Three-dimensional flow contrast imaging of deep tissue using noncontact diffuse correlation tomography,” Applied Physics Letters, 104(12), 121103,2014.

31. Y. Shang, Y. Lin, B.A. Henry, R. Cheng, C. Huang, L. Chen, B.J. Shelton, K.R. Swartz, S.S. Salles, G. Yu, “Noninvasive Evaluation of Electrical Stimulation Impacts on Muscle Hemodynamics via Integrating Diffuse Optical Spectroscopies with Muscle Stimulator,” Journal of Biomedical Optics, 18(10), 105002,2013.

32. L. He, Y. Lin, Y. Shang, B. Shelton, G. Yu, “Using optical fibers with different modes to improve the signal-to-noise ratio (SNR) of diffuse correlation spectroscopy (DCS) flow-oximeter measurements,” Journal of Biomedical Optics, 18(3), 037001,2013.

33. T. Li, Y. Lin, Y. Shang, L. He, C. Huang, M. Szabunio, G. Yu, “Simultaneous measurement of deep tissue blood flow and oxygenation using noncontact diffuse correlation spectroscopy flow-oximeter,” Scientific Reports, 3, 1358,2013.

34. L. Dong, L. He, Y. Lin, Y. Shang, G. Yu, “Simultaneously extracting multiple parameters via fitting one single autocorrelation function curve in diffuse correlation spectroscopy”, IEEE Transactions on Biomedical Engineering, 60(2), 361-368, 2013.

35. R. Srikuea, T. B. Symons, D. E. Long, J. Lee, Y. Shang, P. J. Chomentowski, G. Yu, L. J. Crofford, C. A. Peterson, “Association of fibromyalgia with altered skeletal muscle characteristics which may contribute to postexertional fatigue in postmenopausal women,” Arthritis & Rheumatism, 65(2),519-28,2013.

36. R. C. Mesquita, M. Putt, M. Chandra, G. Yu, X. Xing, S. W. Han, G. Lech, Y. Shang, T. Durduran, C. Zhou, A. G. Yodh, E. R. Mohler, III, “Diffuse optical characterization of an exercising patient group with peripheral artery disease,” Journal of Biomedical Optics, 18(5), 057007,2013.

37. Y. Shang, K. Gurley, G. Yu, “Diffuse Correlation Spectroscopy (DCS) for Assessment of Tissue Blood Flow in Skeletal Muscle: Recent Progress,” Anatomy & Physiology, 3(2), 1000128, 2013.

38. Y. Shang, K. Gurley, B. Symons, D. Long, R. Srikuea, L. J. Crofford, C. A. Peterson, G. Yu, “Noninvasive optical characterization of muscle blood flow, oxygenation, and metabolism in women with fibromyalgia”, Arthritis Research & Therapy, 14, R236,2012.

39. R. Cheng, Y. Shang, D. Hayes, S.P. Saha, G.Yu, “Noninvasive optical evaluation of spontaneous low frequency oscillations in cerebral hemodynamics,” NeuroImage, 62(3), 1445-1454 ,2012.

40. K. Gurley, Y. Shang, and G. Yu, “Noninvasive optical quantification of absolute blood flow, blood oxygenation, and oxygen consumption rate in exercising skeletal muscle,” Journal of Biomedical Optics, 17(7), 075010 ,2012.

41. Y. Lin, L. He, Y. Shang, G. Yu, “Noncontact diffuse correlation spectroscopy for noninvasive deep tissue blood flow measurement,” Journal of Biomedical Optics, 17, 010502 ,2012.

42. L. Chen, Y. Shang, E. Sipos, K. E. Saatman, G. Yu, M Toborek, “Novel experimental model for repeated forebrain ischemia-reperfusion” Journal of Experimental Stroke and Translational Medicine, 5(1), 1-10, 2012.

43. N. Munk, B. Symons, Y. Shang, R. Cheng, and G. Yu, "Noninvasively measuring the hemodynamic effects of massage on skeletal muscle: a novel hybrid near-Infrared diffuse optical instrument," Journal of Bodywork and Movement Therapies, 16(1), 22-28, 2012).

44. L. Dong, M. Kudrimoti, R. Cheng, Y. Shang, E. L. Johnson, S. D. Stevens, B. J. Shelton, and G. Yu, “Noninvasive diffuse optical monitoring of head and neck tumor blood flow and oxygenation during radiation delivery,” Biomedical Optics Express, 3(2), 259-272,2012.

45. Y. Shang, L. Chen, M. Toborek, and G. Yu, "Diffuse optical monitoring of repeated cerebral ischemia in mice," Optics Express, 19(21), 20301-20315, 2011.

46. Y. Shang, R. Cheng, L. Dong, S.J. Ryan, S.P. Saha, and G. Yu, "Cerebral monitoring during carotid endarterectomy using near-infrared diffuse optical spectroscopies and electroencephalogram", Physics in Medicine and Biology 56(10), 3015-32, 2011.

47. G. Yu, Y. Shang, Y. Zhao, R. Cheng, L. Dong, and S.P. Saha, "Intraoperative evaluation of revascularization effect on ischemic muscle hemodynamics using near-infrared diffuse optical spectroscopies," Journal of Biomedical Optics 16(2), 027004,2011.

48. D. Irwin, L. Dong, Y. Shang, R. Cheng, M. Kudrimoti, S.D. Stevens, and  G. Yu, "Influences of tissue absorption and scattering on diffuse correlation spectroscopy blood flow measurements," Biomedical Optics Express 2, 1969-1985, 2011.

49. Y. Shang, T. B. Symons, T. Durduran, A. G. Yodh, and G. Yu, "Effects of muscle fiber motion on diffuse correlation spectroscopy blood flow measurements during exercise," Biomedical Optics Express 1, 500-511, 2010.

50. Y. Shang, Y. Zhao, R. Cheng, L. Dong, D. Irwin, and G. Yu, "Portable optical tissue flow oximeter based on diffuse correlation spectroscopy," Optics Letters 34, 3556-3558,2009.

51. Y. Shang, J. Bai and L. Peng, "The effects of the spatial influence function on orthotropic femur remodeling," Proceedings of the Institution of Mechanical Engineers Part H - Journal of Engineering in Medicine 222 (5), 601-609,2008.

52. Y. Shang, J. Bai, L. Peng and J. Lau, "Comparison of methods for determining orthotropic axes in 3D femur remodeling," Progress in Natural Science 17 (12), 1405-1411, 2007.

（二）SCI期刊編委評述論文:

1. Y. Shang, T. Li and C. Huang, "Editorial: Functional near-infrared diffuse optical spectroscopy (fNIRS) to explore mental health", Front. Psychiatry 13:1021622. 2022.

2. T. Li, Y. Shang, W. Ge, "Optical Technologies for Healthcare and Wellness Applications", Journal of Healthcare Engineering , 1321348 ,2019.

3. Y. Shang, Z. Qian, R.C. Mesquita, M. Dehaes, “Recent Advances in Optical Spectroscopic and Imaging Methods for Medicine and Biology,” Journal of Spectroscopy, 4095790, 2016.

（三）主持的科研項目

1.  “Development of diffuse optical spectroscopies for monitoring cerebral blood flow and oxygenation in mouse stroke model”

   美國心髒協會(AHA)博士後基金#11POST7360020 2011/7/1-2013/6/30

   經費： $88,000

2. “結合形态學影像的近紅外漫射光血流斷層成像系統”

   國家重點研發計劃（科技部）2016YFC0101600 2016/7/1-2018/12/31

   經費：￥1,574,200

3. “結合醫學影像先驗信息的近紅外漫射光血流血氧測量技術研究”

   國家自然科學基金面上項目 61771433    2018/1/1-2018/12/31

   經費：￥188,500

4. “醫學成像與信息處理”

   山西省高等學校中青年拔尖創新人才支持計劃    2018/08/01-2020/12/31

   經費：￥200,000

5. “腦部血流動力學精确測量的近紅外漫射光技術研究”

   山西省重點研發計劃項目201903D121149    2019/07/01-2021/12/31

   經費：￥200,000

6. “基于漫射光自相關技術的動态血流斷層成像研究”

   山西省基礎研究計劃項目 202203021221097 2023/01/01-2025/12/31

   經費：￥100,000

7. “乳腺癌、頭頸癌及腦部檢測的漫射光血流技術方案”

   浙江長興維力華能源科技有限公司 橫向項目  2018/1/10/-2020/1/10

   經費：￥877,700

8. “乳腺癌早期篩查的漫射光血流成像系統組建、校準和評測技術方案”

   香港偉勝科技發展有限公司 橫向項目   2022/1/5/-2022/12/31

   經費：￥517,000

9. “血液動力學成像系統和人工智能影像分析的乳腺腫瘤檢測”

   國家重點研發計劃（科技部）2023YFE0202800    2023/7/1-2025/6/30

   經費：￥4,450,000

（四）授權專利

1. 中國發明專利：ZL201810974797.X

   題目：人腦微血管系統血流的仿體試驗台；授權公告日：2020年4月24日

2. 中國發明專利：ZL201811584435.X

   題目：利用單距離光源-探測器對測量組織飽和度的方法； 授權公告日：2021年7月16日

3. 中國發明專利：ZL201810447228.3

   題目：一種基于NSST和CNN的數字圖像降噪方法； 授權日期：2021年9月21日

 六、獲獎、榮譽稱号

1. 2023年作為指導老師獲得全國大學生生物醫學電子創新設計競賽一等獎

2. 2022年被評為中北大學2022年“師德标兵”榮譽稱号

3. 2022年作為指導教師獲得第十七屆“挑戰杯”全國大學生課外學術科技競賽三等獎

4. 2021年作為指導教師獲得第十六屆中國研究生電子設計競賽全國總決賽二等獎

5. 2021年作為指導教師獲得第七屆山西省“互聯網+”大學生創新創業大賽金獎

6. 2020年作為碩士生導師獲得山西省優秀學位論文（兩篇）

7. 2020年作為指導老師獲得第六屆中國國際“互聯網+”大學生創新創業大賽全國銅獎

8. 2019年入選 “中共山西省委聯系服務的高級專家”

9. 2019年作為指導教師獲得第五屆山西省“互聯網+”大學生創新創業大賽金獎

10. 2019年作為指導教師獲得第十六屆“挑戰杯”全國大學生課外學術科技競賽三等獎

11. 2019年作為指導教師獲得第十四屆中國研究生電子設計競賽全國總決賽二等獎

12. 2018年作為指導老師獲得全國大學生生物醫學電子創新設計競賽二等獎

13. 2017年入選山西省引進海外高層次“百人計劃”；聘任 “山西特聘專家”

14. 2015年入選西安交通大學“青年拔尖人才支持計劃”（特聘研究員）

15. 2015年入選馬奎斯美國名人錄（Marquis Who's Who in America）

16. 當選2012年度Journal of Biomedical Optics  “十佳審稿人(Top 10 reviewers)”

17. 2011年獲得國際會議ECI (Engineering Conferences International)旅行獎金

18. 2005年獲得全國研究生數學建模競賽二等獎

19. 2003作為指導教師獲得高教社杯全國大學生數學建模競賽，獲得全國一等獎、全國二等獎各一項